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229 Adipose tissue acts as an endocrine organ, 230 producing key hormones such as leptin and adiponectin, 231,232 and plays a crucial role in the pathogenesis of T2DM

NNMT is highly expressed in fat tissue, which has made its inhibition a focus of metabolic research

Nong J, Glassman PM, Shuvaev VV, Reyes-Esteves S, Descamps HC, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Gong X, Brysgel TV, Tan AW, Woolfork AG, Weljie A, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA

This review seeks to describe these key immune evasion mechanisms, among others, which schistosomes use to survive in both of their hosts